Abstract #4859

Lactate-weighted Chemical Exchange Saturation Transfer (Lactate-CEST) Imaging in Glioma Patients at 7 Tesla

Daniel Paech¹, Jan-Eric Meissner², Markus Wennmann¹, Andreas Korzowski², Alexander Radbruch¹, Martin Bendszus³, Wolfgang Wick⁴, Andreas Unterberg⁵, Peter Bachert², Mark Edward Ladd², and Heinz-Peter Schlemmer¹

¹Radiology, German Cancer Research Center, Heidelberg, Germany, ²Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, ³Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, ⁴Neurology, University Hospital Heidelberg, Heidelberg, Germany, ⁵Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany

Non-invasive imaging of lactate is of enormous significance, particularly in oncologic diseases or metabolic disorders. In this work, we applied Lactate-weighted Chemical Exchange Saturation Transfer (Lactate-CEST) magnetic resonance imaging (MRI) at 7 Tesla (7T) to newly-diagnosed glioma patients. Lactate-CEST MRI revealed increased levels of lactate production in brain tumors of patients with glioma and could therefore serve as an additional imaging biomarker in diagnostic oncology with implications for biopsy targeting, patient therapy and response monitoring.

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