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Abstract #4862

Predicting efficacy of a novel immune stimulator in an animal model of glioblastoma with ferumoxytol cell tracking MRI

Runze Yang1, A. Max Hamilton1, Susobhan Sarkar2, Reza Mirzaei2, V. Wee Yong2, and Jeff F. Dunn1

1Radiology, University of Calgary, Calgary, AB, Canada, 2Clinical Neuroscience, University of Calgary, Calgary, AB, Canada

Treatment of malignant gliomas with immunotherapy has become an important area of exploration. However, one of the major problems in glioma immunotherapy is the lack of sensitive imaging techniques to differentiate tumor progression (detrimental) from pseudoprogression (beneficial, caused by stimulated macrophages). We hypothesized that tracking macrophages is a sensitive way to detect immunotherapy treatment response. We used a novel drug that stimulates the innate immune system and showed that ferumoxytol based cell tracking MRI is a sensitive way to detect monocyte infiltration and predict tumor growth. Ferumoxytol is used clinically, so this method has high potential for clinical translation

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