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Abstract #4865

23Na MRI at 7 Tesla for Early Response Assessment in Patients with Glioblastoma and Skull Base Meningioma

Sebastian Regnery1,2, Daniel Paech3, Heiz-Peter Schlemmer3, Mark E. Ladd4, Armin M. Nagel4,5, Stefan Rieken1,2, J├╝rgen Debus1,2, Sebastian Adeberg1,2, and Nicolas G.R. Behl4

1Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany, 2Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Radiotherapy is a cornerstone in the treatment of glioblastoma and skull base meningioma. Here, the first results of a prospective longitudinal study employing 23Na MRI for the response evaluation of glioblastoma and skull base meningioma patients during radiotherapy are presented. The study results show that radiation treatment of glioblastoma leads to considerable changes in sodium concentrations within the tumor and the surrounding edema that are dependent on treatment response.

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