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Abstract #4909

MRI-based retrospective gating for PET reconstruction in rats: implementation and proof of principle study

Willy Gsell1, Uwe Himmelreich1, Arno Nauerth2, Cesar Molinos3, Carlos Correcher3, Antonio J Gonzalez4, Sven Junge2, Thorsten Greeb2, Ramiro Polo3, Bryan Holvoet5, Christophe M Deroose5, and Michael Heidenreich2

1Biomedical MRI, KU Leuven, Leuven, Belgium, 2Preclinical Imaging PCI, Bruker Biospin MRI, GmbH, Ettlingen, Germany, 3Preclinical Imaging NMI, Bruker Biospin MRI, GmbH, Valencia, Spain, 4Institute for Instrumentation in Molecular Imaging, i3M-CSIC, Valencia, Spain, 5Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium

We hereby report the implementation and the preliminary results of an MRI-based retrospective gating strategy for reconstructing simultaneously acquired PET data in rats (SPECMRI). Ejection fraction extracted from MRI, SPECMRI and ECG-gated PET were all within the same range (70.0 ± 3.5%, 72.5 ± 5.4% and 70.5 ±6% for MRI, ECG-gated and SPECMRI respectively). This new technique enables to ease the animal handling (no need for ECG electrodes) and provide true synchronization of PET and MRI data.

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