Cancer cells may use altered metabolic pathways with respect to their normal counterparts; this metabolic switch is necessary to support their rapid proliferation in oxygen- and nutrient-poor conditions. A few of the metabolites are up-regulated while some others are down-regulated or unaltered. High grade malignant tumors present with enhancement on T1-weighted (T1w) image. Enhancement on post-contrast T1w images is an indicative of breakdown of blood brain barrier (BBB). The increased number of tumor cells may stress the vessels and, thus BBB tend to rupture. A non-invasive bio-marker that can predict the disruption of BBB will be of great clinical significance for assessing the tumor aggressiveness. Here, we show elevated Gly can be a potential bio-marker for predicting the tumor’s potential to present with ruptured BBB.