One major application of FUS is the opening of the blood brain barrier (BBB) to target the brain cells with drugs such as in glioma. While the impact of FUS on brain disease is under intense evaluation, its impact of normal brain physiology has received less attention. In this study, we evaluate the impact of BBB opening using FUS on cerebral blood flow (CBF), assessed by pseudo-continuous arterial spin labeling (ASL). Following 0.6MPa FUS at 1.2Mhz, a small change in ADC was observed, suggesting a small vasogenic edema. In addition, there was a 50%CBF reduction in a large vascular territory.