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Abstract #4945

DTI Connectome Analysis in Moderate TBI: Parcellation Improves Detection of Relevant Injury and the Monitoring of Therapeutic Response

TALAIGNAIR N VENKATRAMAN1, RYAN PEARMAN2, HAICHEN WANG3, CHRIS PETTY2, ALLEN W SONG2, DANIEL T LASKOWITZ3, and CHRISTOPHER D LASCOLA2

1DUKE UNIVERSITY MEDICAL CENTER, DURHAM, NC, United States, 2RADIOLOGY, DUKE UNIVERSITY MEDICAL CENTER, DURHAM, NC, United States, 3NEUROLOGY, DUKE UNIVERSITY MEDICAL CENTER, DURHAM, NC, United States

Conventional DTI readouts such as fractional anisotropy (FA), axial diffusion (RD) and radial diffusion (RD) show distinct alterations following closed head injury but do not correlate well with measured functional and cognitive outcomes. 3D DTI with parcellated connectome analysis reveals neural fiber networks between brain regions that are most vulnerable to closed head (acceleration-deceleration) injury and also most relevant to measurable functional deficits. In this study, fiber tract number between hippocampus and cortex is the most sensitive marker of both motor and memory deficits and therapeutic improvement following administration of a novel neuroprotective therapeutic agent.

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