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Abstract #4951

Transient neuronal dysfunction correlates with hypo-perfusion in patients with moderate post-traumatic brain injury

Eva-Maria Ratai1,2, Suk-tak Chan2,3, Maria Gabriela Figueiro Longo4, Michael Wenke1, Termara Parker1, Jonathan Welt2,5, Joyce van Loon4, Emad Ahmadi1, Anastasia Yendiki2,3, Jacqueline Namati2,5, Isabel Chico-Calero2,5, Blair Parry6, Can Ozan Tan2,7, Jarone Lee2,8, Michael Lev2,9, Michael Hamblin2,5, Benjamin Vakoc2,5, and Rajiv Gupta1,2

1Department of Radiology / Neuroradiology Division, Massachusetts General Hospital/ A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Radiology, Massachusetts General Hospital/ A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States, 6Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States, 7Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation, Charlestown, MA, United States, 8Department of Emergency Medicine and Department of Surgery, Massachusetts General Hospital, Boston, MA, United States, 9Emergency Radiology and Emergency Neuroradiology, Massachusetts General Hospital, Boston, MA, United States

We present a DOD funded study to assess the effects of low-level light therapy (LLLT) on metabolites measured by MRS and cerebral perfusion measured by ASL using a double-blind, placebo controlled study where patients with moderate TBI were randomized between LLLT and sham treatment. We report CBF and metabolic changes pertaining to neuronal injury and neuroinflammation for the entire cohort (i.e., both treated and control arms), before the blind is broken. Our findings suggest that transient neuronal dysfunction in the posterior cingulate cortex and neuroinflammation in the thalamus correlated with hypo-perfusion during the subacute phase of moderate TBI.

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Abstract