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Abstract #4960

Assessment of metabolic changes in traumatic brain injury using hyperpolarized [1-13C]pyruvate: a longitudinal study

Edward Hackett1, Laura Ingle2, Brenda Bartnik-Olson3, and Jae Mo Park1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Radiology, Loma Linda University, Loma Linda, CA, United States

In this study, we longitudinally assessed acute metabolic changes during 2-120hrs post traumatic brain injury in a controlled-cortical impact rat model using hyperpolarized [1-13C]pyruvate. We observed mildly increased pyruvate conversion to lactate and significantly reduced bicarbonate production in the injured site at 24hrs after impact. Conversely, lactate was reduced when measured at 48hrs-post injury. Bicarbonate production in the lesion remained low with significantly increased bicarbonate production in the contralateral normal-appearing brain

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