Abstract #4967

Assignment of Two More Fucose-α-(1-2)-Galactose Glycans in the Human Brain Linked in Animal Models to Learning and Memory

Nathan Tosh^1,2, Scott Quadrelli^1,3, Graham Galloway¹, and Carolyn Mountford¹

¹Translational Research Institute, Brisbane, Australia, ²Faculty of Health, Queensland University of Technology, Brisbane, Australia, ³University of Newcastle, Newcastle, Australia

Two-dimensional COSY scans at 3T using a 64 channel head and neck coil have enabled the inspection of fucose-α-(1-2)-galactose glycans that resonate in the region of F1=0.9-1.7ppm; F2= 4.1-4.5ppm. With accurate shimming and water suppression, two new peaks were identified (Fuc VI at 4.44-1.37 ppm and Fuc VII at 4.29-1.36 ppm). These cross-peaks were consistently visualised across 86 participants.

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