Abstract #4977

Longitudinal evaluation of lesion pathology in a novel murine model for Multiple Sclerosis

Caroline Guglielmetti^1,2, Christian Cordano³, Ari Green³, and Myriam Chaumeil^1,2

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ³Department of Neurology, University of California San Francisco, San Francisco, CA, United States

We used conventional MRI to longitudinally assess lesion pathology in a combined cuprizone and experimental autoimmune encephalomyelitis (CPZ/EAE) model. The novelty of this model lies in the recruitment of cells from the innate and adaptive immune system into brain lesions. We used T₂-weighted imaging to monitor white matter lesions. Interestingly, we showed a transient change in T₂ contrast at the onset of clinical symptoms in the CPZ/EAE group. Using gadolinium-enhanced MRI, we showed transient opening of the blood-brain-barrier prior and/or following clinical symptoms. Altogether, these findings are of relevance to understand the dynamics of lesion formation in a novel MS model.

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