Abstract #5003

Quantitative Susceptibility Mapping of Articular Cartilage in Patients with Osteoarthritis

Hongjiang Wei¹, Huimin Lin², Yuyao Zhang¹, Weibo Chen³, Fuhua Yan², and Chunlei Liu¹

¹University of California, Berkeley, Berkeley, CA, United States, ²Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Philips Healthcare, Shanghai, Shanghai, China

Osteoarthritis (OA) is a multifactorial degenerative joint disease and is the most common form of arthritis which characterized by degenerative changes in the cartilage, menisci, ligaments and bone. The purpose of this study is to evaluate the magnetic susceptibility changes in knee diseases, such as patients with bone marrow lesions and cartilage loss. Clear susceptibility contrast was observed between bone marrow lesions and surroundings. The multilayer pattern of the damaged cartilage was lost compared with that of healthy subjects. QSM may provide a new way to improve the characterization of tissue microstructure in the knee joint related to osteoarthritis.

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