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Abstract #5032

A compact solution for physiological parameters from ultrafast prostate DCE-MRI may reduce random and systematic errors

Xiaobing Fan1, Dianning He2, Aritrick Chatterjee1, Shiyang Wang1, Milica Medved1, Federico D Pineda1, Ambereen Yousuf1, Tatjana Antic3, Aytekin Oto1, and Gregory S Karczmar1

1Radiology, The University of Chicago, Chicago, IL, United States, 2Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China, 3Pathology, The University of Chicago, Chicago, IL, United States

The Tofts pharmacokinetic model requires multiple calculations for analysis of dynamic contrast enhanced (DCE) MRI. This can result in error propagation that reduces the accuracy of pharmacokinetic measurements. Here, we present a new compact solution for estimating physiological parameters based on changes in signal intensity, without the Tofts model. Human prostate DCE-MRI data were analyzed to compare physiological parameters estimated from proposed compact solution with the Tofts model. The Ktrans and ve from the compact solution correlated strongly with values from the Tofts Model. Bland–Altman plots showed moderate to excellent agreement between the compact solution and the Tofts Model.

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