Abstract #5059

Decreasing Water T2 based on multi-TE single-voxel MRS in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Sarah Schlaeger^1,2, Dominik Weidlich¹, Elisabeth Klupp², Federica Montagnese³, Marcus Deschauer⁴, Benedikt Schoser³, Sarah Bublitz⁴, Claus Zimmer², Ernst J. Rummeny¹, Jan S. Kirschke², and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, ²Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, ³Friedrich-Baur-Institut, Ludwig Maximilian University, Munich, Germany, ⁴Department of Neurology, Technical University of Munich, Munich, Germany

Quantitative imaging techniques are emerging in the field of magnetic resonance imaging of neuromuscular diseases. Water T2 and proton density fat fraction are the most important imaging markers to assess edematous and fatty transformation in the patients’ muscle tissue. To validate the accuracy of quantitative methods ¹H magnetic resonance spectroscopy can be used as a reference standard. The present study investigates water T2 of remaining muscle tissue in regions of higher proton density fat fraction in 42 patients with various neuromuscular diseases using multi-TE single-voxel MRS.

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