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Abstract #5073

Exercise-induced muscle hypoxia and re-oxygenation in the calf: A comparison between Near Infra-Red Spectroscopy (NIRS) and BOLD MRI

Christopher C Conlin1, Jiawei Dong1, Stephen Decker2, Gwenael Layec2, Vivian S Lee1, and Jeff L Zhang1

1Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT, United States, 2Division of Geriatrics, University of Utah School of Medicine, Salt Lake City, UT, United States

This study compared calf-muscle oxygenation measurements from BOLD MRI and near-infrared spectroscopy (NIRS) in a group of healthy subjects after plantar-flexion exercise. NIRS measurement of deoxyhemoglobin (dHb) was limited to the medial gastrocnemius, while BOLD imaging allowed for R2* mapping of the entire calf. Post-exercise R2* recovery dynamics in the calf indicated significant functional differences between different calf muscle groups. This advantage of BOLD makes it potentially valuable for assessing peripheral arterial disease (PAD), where impairment of muscle function can vary depending on the location of upstream stenosis.

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