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Abstract #5080

Association of thigh muscle fat infiltration with isometric strength measurements based on chemical shift encoding-based water–fat MRI

Thomas Baum1, Sarah Schlaeger1, Stephanie Inhuber2, Florian Kreuzpointer2, Michael Dieckmeyer3, Friedemann Freitag3, Elisabeth Klupp1, Barbara Cervantes3, Ansgar Schwirtz2, Jan S Kirschke1, and Dimitrios C Karampinos3

1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany, 3Department of Radiology, Technical University of Munich, Munich, Germany

Chemical shift encoding-based water–fat MRI derived proton density fat fraction (PDFF) of the thigh muscles has been emerging as surrogate marker in subjects with osteoarthritis, sarcopenia, and neuromuscular disorders. However, little is known about the relationship of thigh muscle PDFF and corresponding muscle strength measurements. The present study demonstrated that PDFF measurements improve the prediction of thigh muscle strength beyond muscle cross-sectional area in healthy subjects. Thus, chemical shift encoding-based water–fat MRI can provide clinically important information and may potentially track early changes in muscles that are not severely atrophied or fattily infiltrated.

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