We evaluated the ability of spin-lock imaging to detect the uptake of 3-o-methyl-D-glucose (3oMG) in normal brain and brain tumors in animals. We used $$$\triangle R_{1\rho}^{diff}$$$ to isolate the contribution from only the injected agent. We found that $$$\triangle R_{1\rho}^{diff}$$$ in tumors increased rapidly after injection, whereas intact brain showed a gradual increase up to 1h. $$$\triangle R_{1\rho}^{diff}$$$ was significantly different between tumors and contralateral normal tissues
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