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Abstract #5155

Ultra-short echo time (UTE) imaging with Three-component fitting analysis of human cortical bone

Xing Lu1,2, Saeed Jerban1, Michael Carl3, Wenhui Yang2, Annette von Drygalski4, Eric Y Chang5, and Jiang Du1

1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China, 3GE Healthcare, San Diego, CA, United States, 4Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, San Diego, CA, United States, 5Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Increased cortical porosity is a major cause of the decreased strength of osteoporotic bone, which can be evaluated by MRI based bone water components analysis. The chemical shift caused by fat in the bone may lead to incorrect estimation of water components with a bi-component exponential model. Thus, we propose a tri-component fitting method for accurate bound and pore water quantification incorporating a multi-peak spectral modeling of fat. Nine human cortical bone samples were studied. Our results suggest improved curve fitting and additional information when a tri-component analyses is used.

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