Osteosarcoma(OS) and Ewing’s sarcoma family of tumors(ESFT) are the most common primary malignant bone tumor in children and adolescents. As the patient’s age, presenting signs & symptoms and qualitative imaging features are common in both, there could be a diagnostic dilemma that can only be resolved by biopsy & histopathological assessment. Texture analysis in Diffusion Weighted Imaging(DWI) might provide additional useful information as DWI captures early cellular changes within tumors. We computed textural features in patients with OS and ESFT. Experimental results revealed that textural features provided significant discrimination between OS and ESFT; thus might be useful as diagnostic marker.