Meeting Banner
Abstract #5189

Imaging low grade inflammation in post-traumatic osteoarthritis

Amparo Ruiz1, Alejandra Duarte1, Mark Milne2, Zahid Dewan1, Len Luyt2, and José G Raya1

1New York University, New York, NY, United States, 2University of Western Ontario, London, ON, Canada

Chronic inflammation has been identified as a major driver of joint degradation after injury. MRI is very limited to assess chronic inflammation with high specificity. Here we propose a novel contrast agent that targets the interaction of hyaluronan with RAMM cell receptors that represent an important signaling pathway for chronic inflammation. We validated the contrast agent with optical imaging and showed its value as an MRI contrast agent.

This abstract and the presentation materials are available to members only; a login is required.

Join Here