Meeting Banner
Abstract #5237

Voxel size matters: big voxels are required to generate realistic extra-axonal dMRI signals from Monte Carlo simulations

David Romascano1,2, Jonathan Rafael-Patino1, Ileana Jelescu3, Muhamed Barakovic1, Tim B. Dyrby2,4, Jean-Philippe Thiran1,5, and Alessandro Daducci1,5,6

1Signal Processing Lab 5 (LTS5), EPFL, Lausanne, Switzerland, 2Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 3Centre d'Imagerie Biom├ędicale, EPFL, Lausanne, Switzerland, 4Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 5Department of Radiology, University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6Computer Science department, University of Verona, Verona, Italy

Monte Carlo simulations provide diffusion MRI signals that can be used to evaluate microstructure models, but that can also be incorporated into microstructure reconstruction methods. It is therefore important for the generated signals to be as realistic as possible. This work shows preliminary evidence that, in the case of white matter models, the symmetry of the perpendicular extra-axonal signal generated with Monte Carlo simulations depends on the voxel size. Simulations corresponding to millimeter-sized voxels should therefore be computed using substrates of equivalent size, or by averaging signals generated from multiple small voxels.

This abstract and the presentation materials are available to members only; a login is required.

Join Here