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Abstract #5243

Quantification of white matter pathologies by a diffusion MRI technique modeling both intra- and extra-axonal compartments

Chunyu Song1, Tsen-Hsuan Lin2, Peng Sun3, and Sheng-Kwei Song3

1Biomedical Engineering, Washington University in St. Louis, st louis, MO, United States, 2Radiology, Washington University School of Medicine, St louis, MO, United States, 3Radiology, Washington University School of Medicine, St Louis, MO, United States

A new diffusion MRI histology (D-Histo) is proposed to model both intra- and extra-axonal diffusion as well as isotropic diffusion components within an image voxel. Both Monte-Carlo simulation, in vivo MRI of EAE mouse optic nerve, and post-MRI histology were used to validate this approach. The intra-axonal fraction derived from D-Histo more accurately assessed fiber fraction, and the intra-axonal axial diffusivities (AD) it derives more sensitively reflected axonal injury.

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