Purpose: To investigate the potential of R1-weighted Synthetic-MRI for unraveling the microstructure of white matter and for constructing accurate high resolution brain connectomes. Methods: Eighteen research subjects ranging in age from 0.6 to 87years were scanned with multispectral qMRI (T1, R1, T2, and PD) and analyzed with R1-weighted Synthetic MRI. Results: connectome renderings as function of increasing age show the expected increased WM track bundle packing and anatomical distributions evolution as function of age. Conclusion: R1-weighted WM Fibrography is a promising complementary alternative to DTI-WM Tractography for studying the microarchitecture of white matter.
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