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Abstract #5267

Evaluating the effect of 3-n-butylphthalide on expression of aquaporin-4 by ultra-high b value diffusion weighted imaging in animal model with focal cerebral ischemia

Baohong Wen1, Dandan Zheng2, and Jingliang Cheng1

1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare, China, Beijing, China

Previous studies have reported that 3-n-butylphthalide (NBP) had beneficial effects on stroke through multiple aspects, including decreasing the area of cerebral infarct, improving energy metabolism , inhibiting the inflammatory response and improving cerebral microvessels . Although the positive effects of NBP on cerebral ischemia and cerebral infarct have been verified in ischemic patients and animal models, the effects of NBP in aquaporin-4 (AQP-4) are still unclear. Recently, ultra-high diffusion weighted imaging was reported to be able to reflect AQP-4 changes . This study would like to evaluate the effect of 3-n-butylphthalide on expression of aquaporin-4 by ultra-high b value diffusion weighted imaging in animal model of focal cerebral ischemia at different time points.

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