Christina Andica1, Akifumi Hagiwara1,2, Keigo Shimoji3, Koji Kamagata1, Asami Saito1, Yuki Takenaka1,4, Tomoko Maekawa1,2, Saori Koshino1,2, Ryusuke Irie1,2, Akihiko Wada1, Masaaki Hori1, Kanako K Kumamaru1, Kanako Sato1, Kazumasa Yokoyama5, Nobutaka Hattori5, and Shigeki Aoki1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan, 4Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 5Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Our study demonstrated that myelin volume fraction (MVF) and myelin volume (MyV) obtained by a multi-parametric quantitative synthetic MRI might be useful for evaluating gray matter (GM) myelin alterations and for monitoring disease progression in relapsing-remitting multiple sclerosis (RRMS) patients. GM-based spatial statistics analysis demonstrated decreased MVF in limbic, paralimbic, and deep GM areas in the early-RRMS, and in extensive areas of GM in the late-RRMS. In the meanwhile, MyV was found to be decreased in both RRMS groups compared to healthy subjects, with late-RRMS showing the lowest value, and significantly correlated with disease duration.