Meeting Banner
Abstract #5275

MR Microscopy of Cortical Lesions Reveal Iron Loss in Individual Oligodendrocytes

Stephen Dodd1, Govind Nair2, Seung-Kwon Ha3, Daniel Reich3, and Alan Koretsky1

1Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States, 2Neuroimmunology Clinic, NINDS, National Institutes of Health, Bethesda, MD, United States, 3Translational Neuroradiology Section, NINDS, National Institutes of Health, Bethesda, MD, United States

Imaging of cortical demyelination in chronic multiple sclerosis, has been challenging. Previous MRI studies have detecting signal changes in cortical lesions have been attributed to myelin loss and the presence of iron-laden microglia. Here we demonstrate, in a case study, that MR microscopy may readily identify individual iron-rich cells (primarily oligodendrocytes) and regions. In addition, MR microscopy is shown to allow detailed examination of the central vein signal in white matter lesions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here