Meeting Banner
Abstract #5276

Inconsistency in Grey Matter Volume Estimation of MS Patients: A Multi-Vendor Study at 3 Tesla

Houshang Amiri1, Stephanie Bosschaert1, Iman Brouwer1, Joost P.A. Kuijer1, Jan C. de Munck1, Marloes Hagens2, Joep Killestein2, Frederik Barkhof1,3, and Hugo Vrenken1

1Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, 2Department of Neurology, MS Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands, 3Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom

MR images are widely used to measure brain atrophy is neurodegenerative diseases. However, reliable evaluation of atrophy is hampered by between- and within-scanner variability and inconsistency. We investigated this in 21 multiple sclerosis patients scanned at three different scanners (twice at each scanner). Volumes of GM, WM and whole brain, as well as deep grey matter structures were assessed using SIENAX and FSL-FIRST, respectively. Voxel-based morphometry was used to localise variabilities in the brain. Our findings suggests that scanner-related factors, and especially between-scanner variability, play a role in inconstancy of brain volume measurements.

This abstract and the presentation materials are available to members only; a login is required.

Join Here