Abstract #5289

Accelerated Isotropic Sub-Millimeter Whole-Brain Susceptibility Imaging at 3T: Application to Multiple Sclerosis

Sunil Patil¹, Henrik Odéen², J. Andrew Derbyshire³, Gunnar Krueger⁴, Dennis L. Parker², Himanshu Bhat⁵, Daniel S. Reich⁶, and Pascal Sati⁶

¹Siemens Medical Solutions USA, Inc, Baltimore, MD, United States, ²Radiology and Imaging Sciences, University Of Utah, Salt Lake City, UT, United States, ³Section of Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, ⁴Siemens Healthcare, Zurich, Switzerland, ⁵Siemens Medical Solutions USA, Inc, Boston, MA, United States, ⁶Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

High-resolution susceptibility-weighted MRI has recently gained attention as a novel imaging biomarker in multiple sclerosis (MS) such as the ‘central vein sign’ and ‘phase rims’. This preliminary study demonstrates the feasibility of an accelerated volumetric (3D) segmented echo-planar-imaging (EPI) sequence, which allows acquiring whole brain images at 0.65 mm isotropic resolution in approximately 3 minutes. Both magnitude (T2^*-weighted) and phase (QSM) information were interpretable and displayed characteristic features of MS lesions. This accelerated 3D EPI anatomical acquisition shows potential to open the door to routine high-resolution susceptibility-weighted imaging to better support diagnosis and therapy monitoring in MS patients.

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