Plot of spinal cord cross-sectional area (SCCSA) from C1 to T10 reveals distinct patterns in various multiple sclerosis subtypes. While the relapsing remitting subtype revealed thinner cord in the cervical region, progressive subtypes had thinner c- and t-spines compared to healthy subjects. SCCSA measures were related to clinical outcomes, and revealed that up to 10-15% of disability can be explained by differences in SCCSA alone. Furthermore, segregating patients based on the SCCSA seems to give a better stratification of their clinical disability. This study suggests SCCSA can be used as an outcome measure in clinical trials.