Meeting Banner
Abstract #5300

Subcortical and medial temporal lobe shape changes following electroconvulsive therapy

Filip Bouckaert1,2,3, Jurgen Germann4, Mallar Chakravarty4, Annemieke Dols5,6, Fran├žois-Laurent De Winter1,3, Lies Van Assche1,3, Jan Van den Stock1,3, Stefan Sunaert7,8, Max Stek5,6, Pascal Sienaert2, Mathieu Vandenbulcke1,3, and Louise Emsell1,3,7,8

1Old Age Psychiatry, UPC KU Leuven, Leuven, Belgium, 2Academisch Centrum voor ECT en Neuromodulatie (AcCENT, UPC KU Leuven, Kortenberg, Belgium, 3Laboratory for Translational Neuropsychiatry, Dept Neurosciences, KU Leuven, Leuven, Belgium, 4Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada, 5Old Age Psychiatry, GGZ in Geest, Amsterdam, Netherlands, 6Old Age Psychiatry, VU Medical Center, Amsterdam, Netherlands, 7Translational MRI, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium, 8Radiology, UZ Leuven, Leuven, Belgium

Electroconvulsive therapy is a safe, rapid-acting antidepressant treatment that has consistently been associated with grey matter (GM) volume increase, primarily in the medial temporal lobe (MTL). Here we replicate and extend previous studies by demonstrating substantial surface area and local displacement changes in subcortical and MTL GM one week following the last ECT treatment in 70 patients with late-life depression. We report new data on ECT induced thalamus shape changes, and demonstrate that whilst the number of ECT treatments correlates positively with the degree of medial temporal GM surface area increase, this is not associated with clinical improvement in mood.

This abstract and the presentation materials are available to members only; a login is required.

Join Here