Abstract #5307

Multimodal metabolic imaging using single voxel MRS and [11C]ABP688 PET in Schizophrenic Patients

Linda Orth^1,2, Ravichandran Rajkumar^1,2,3,4, Cláudia Régio Brambilla ¹, Ezequiel Farrher¹, Andreas Matusch⁵, Shukti Ramkiran¹, Andrej Ruch ², Jörg Mauler¹, Elena Rota Kops¹, Lutz Tellmann¹, Jürgen Scheins^1,4, Bernd Neumaier⁶, Markus Lang⁶, Johannes Ermert⁶, Hans Herzog¹, Karl-Josef Langen^1,3,7, Christoph Lerche^1,4, N. Jon Shah^1,3,4,8,9,10, and Irene Neuner^1,2,3,4

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, Jülich, Germany, ⁴TRIMAGE – consortium (http://www.trimage.eu/), Jülich, Germany, ⁵Institute of Neuroscience and Medicine 2, INM-2, Forschungszentrum Jülich, Jülich, Germany, ⁶Institute of Neuroscience and Medicine 5, INM-5, Forschungszentrum Jülich, Jülich, Germany, ⁷Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁸Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich, Jülich, Germany, ⁹Department of Neurology, RWTH Aachen University, Aachen, Germany, ¹⁰Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

By utilizing a multimodal imaging approach, the levels of glutamate and other metabolites in the anterior cingulate and the posterior cingulate cortex were assessed by MRS and compared to the metabotropic glutamate receptor 5 (mGluR5) binding potential using [¹¹C]ABP688 PET in schizophrenic patients and healthy controls. Glutamate levels seem to be elevated in schizophrenic patients. PET analysis revealed no differences in binding potential (BP_ND) in both diagnostic groups. However, adding smoking status to analysis, there is a significant reduction in BP_ND in smokers compared to non-smokers, suggesting a connection between mGluR5 binding potential and nicotine dependence.

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