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Abstract #5312

Alterations in functional brain network topology in Tourette’s syndrome

Shukti Ramkiran1, Larissa Heidemeyer2, Ravichandran Rajkumar1,2,3,4, N Jon Shah1,3,4,5,6,7, and Irene Neuner1,2,3,4

1Institute of Neuroscience and Medicine - 4, INM-4, Forschungszentrum Juelich, Juelich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA-BRAIN Translational Medicine, Aachen, Germany, 4TRIMAGE – consortium, Aachen, Germany, 5Institute of Neuroscience and Medicine - 11, INM-11, Forschungszentrum Juelich, Juelich, Germany, 6Department of Neurology, RWTH Aachen University, Aachen, Germany, 7Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash Institute of Medical Engineering, Monash University, Melbourne, Australia

Tourette syndrome (TS) is a neurodevelopmental disorder with typical onset in childhood. Its characteristic motor tics are said to be attributed to dysfunction in the cortico-striato-thalamo-cortical circuit and cerebellar communication. Brain functional connectivity along with network topology analysis provides a useful tool to understand communication strategies in the brain. Hence we aim to investigate alterations in functional and effective connectivity in brains of patients with TS. Based on prior results1,2, we hypothesize that connectivity of basal ganglia, thalamus and cerebellum with other regions will be altered.

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