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Abstract #5314

Meta-analytic investigations of grey matter alterations in patients with anorexia nervosa.

Simin Zhang1, Weina Wang1, Xiaorui Su1, Qiyong Gong1, and Qiang yue1

1HMRRC,Department of Radiology,West China Medical School of Sichuan University, Chengdu, China

The purpose of the present Meta-analytic study was to summarize the grey matter volumetric alterations and elucidate how the changes were associated with symptoms and pathophysiology in anorexia nervosa(AN). We use effect-size signed differential mapping (ES-SDM) to conduct meta-analytical whole brain volumetric differences between patients AN and healthy controls (HCs). The studies showed volume reduction in bilateral median cingulate cortex(MCC), posterior cingulate cortex (PCC), precuneus, supplementary motor area(SMA) and left cerebellum, which provide evidence for abnormalities in emotion regulation, behavior regulation and sensorimotor area in nervosa anorexia.

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