The comparisons of mean displacement (MD) from multi-shell QSI (msQSI) and grid sampling QSI (gsQSI) were executed by anisotropic diffusion phantom and human brain. In addition, the effect of the number of slices excited and acquired simultaneously (SMS factor) we also investigated. The MDs of msQSI and gsQSI were different. The shorter diffusion time on gsQSI might effect these differences. SMS factors on msQSI showed difference among the acceleration. On contrary, SMS factors on gsQSI did not show any difference among the acceleration.