Abstract #5363

Non-Gaussian DWI of breast lesions at high b-values

Igor Vidic¹, Liv Egnell^1,2, Neil P. Jerome^2,3, Torill E. Sjøbakk³, Agnes Østlie², Hans E. Fjøsne^4,5, Roshan Karunamuni⁶, Nathan S. White^7,8, Rebecca Rakow-Penner⁷, Anders M. Dale^7,9, Tone F. Bathen³, and Pål Erik Goa^1,2

¹Department of Physics, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ²Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway, ³Department of Circulation and Medical Imaging, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ⁴Department of Cancer Research and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ⁵Department of Surgery, St. Olavs University Hospital, Trondheim, Norway, ⁶Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, United States, ⁷Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ⁸Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, United States, ⁹Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States

In this work, we fit multiple non-Gaussian models to high b-value DW-MRI (b= 200-3000 s/mm²) in benign and malignant breast lesions. Models included bi-exponential, stretched exponential, diffusion kurtosis, Padé exponent and ADC (for comparison). We evaluated the quality of fit for each model and investigated the lesion differentiation accuracy for all extracted model parameters. The bi-exponential model provided statistically significant better quality of fit than all the other models, and without systematic bias. This suggests the existence of two effective diffusion compartments in breast lesions. Several of the extracted model parameters performed equally well in terms of lesion differentiation (AUC>0.97).

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