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Abstract #5369

Brain axonal and myelin changes after positive airway pressure treatment in patients with obstructive sleep apnea

Ashish Kaul Sahib1, Bhaswati Roy2, Xiaopeng Song1, Sadhana Singh1, Luke Ehlert1, Ravi Aysola3, Daniel Kang3, Mary Woo2, and Rajesh Kumar1,4,5,6

1Departments of Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, 2UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, 3Medicine, University of California at Los Angeles, Los Angeles, CA, United States, 4Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, 5Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, 6Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

Newly-diagnosed, treatment-naïve obstructive sleep apnea subjects show predominately acute tissue changes in gray and white matter, in addition to autonomic, mood, and cognitive deficits, but the extent of brain tissue recovery after PAP treatment and required minimum treatment time is unclear. We examined brain axonal and myelin changes at baseline and tissue recovery after 3 and 9 months’ positive airway pressure treatment in OSA compared to control subjects. Our findings indicate that brain structural changes found in newly-diagnosed OSA subjects can be reversible with long-term PAP treatment.

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