Abstract #5372

Using Double Diffusion Encoding (DDE) MRI to study tissue microstructure in traumatic brain injury (TBI)

Michal E Komlosh^1,2, Dan Benjamini¹, Elizabeth B Hutchinson^2,3, Sarah King^2,3, Margalit Haber⁴, Alexandru V Avram¹, Lynne A Holtzclaw⁵, Abhishek Desai⁶, Carlo Pierpaoli ³, and Peter J Basser¹

¹Section on Quantitative Imaging and Tissue Sciences, NICHD, National Institutes of Health, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, Uniform Service University of the Health Sciences, Bethesda, MD, United States, ³Quantitative Medical Imagion Section, NIBIB, National Institutes of Health, Bethesda, MD, United States, ⁴Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Microscopy and Imaging Core, NICHD, National Institutes of Health, Bethesda, MD, United States, ⁶Laboratory of Molecular Signaling, NIAAA, National Institutes of Health, Rockville, MD, United States

A double diffusion encoding (DDE) MRI method was used to estimate apparent mean axon diameter (AMD) in a mild traumatic brain injury (mTBI) mouse model exhibitig diffuse axonal injury (DAI). MRI data show clear tissue alterations caused by the injury, while immunohistochemistry data confirm the MRI findings. DDE could potentially be used as a non-invasive means to detect mTBI.

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