Primary brain gliomas are very a widespread type of intra-axial brain tumours. Brain gliomas have different cellular origins and can be differentiated by WHO 2016 classification. The most aggressive type of glioma is the glioblastoma (GB). Thus, a correct and reliable grading of gliomas, in particular, the GB, is critical for a patient treatment and prognosis. Diffusion kurtosis imaging (DKI) has been applied to glioma validation in order to perform non-invasive evaluation. DKI allowed one to obtain information about microstructure and inhomogeneity differentiation. In the present work we demonstrate advantages of generalised DKI approach for GB detection and evaluation.