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Abstract #5425

The Impact of Prenatal Endocrine-Disrupting-Chemical Exposure on Brain Function in Teenagers

Chi-Ieong Hong1, Shu-Li Wang2, Chao-Yu Shen1,3, Jeng-Dau Tasi4, Tou-Rong Chen1, and Jun-Cheng Weng5,6

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan, 3Institute of Medicine and Department of Medical Imaging, Chung Shan Medical University and Hospital, Taichung, Taiwan, 4School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan, 5Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 6Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

The products made by endocrine disrupting chemicals (EDCs) widely exists in our daily life, which could be a risk of our health. We tried to find the relationship between prenatal exposure to EDCs’ concentrations and teenager’s brain function using resting-state functional MRI (rs-fMRI). Our results showed the correlation between prenatal perfluorononanoic acid (PFNA)/MeHg exposure and functional alterations of the teenage brain in caudate gyrus and putamen.

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