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Abstract #5499

In vivo high-field myelin water imaging: Investigating the T2 distribution at 7T

Vanessa Wiggermann1,2,3, Alex L MacKay1,2,4, Gunther Helms5,6, and Alexander Rauscher1,2,3,7

1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4Radiology, University of British Columbia, Vancouver, BC, Canada, 5Swedish National 7T MRI Facility, Lund University, Lund, Sweden, 6Medical Radiation Physics, Lund University, Lund, Sweden, 7BC Children's Research Centre, University of British Columbia, Vancouver, BC, Canada

With the increased frequency of human 7T scanners, there is also a drive towards the implementation advanced MR sequences, such a myelin water imaging, at high fields. Here, we demonstrate the feasibility of translating 3T myelin acquisitions scheme, GRASE, to 7T. We studied the distribution of T2 values at 7T and determined that myelin water has a T2<25ms. We obtained excellent agreement for myelin water fraction values in the corpus callosum between 3T and 7T.

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