Previous authors have attempted to utilize the microsphere model and a maximum gradient (MG) based approach to estimate cerebral blood flow from DCE MRI data, which, however, was not widely accepted. This study developed a new methodology based on the microsphere theory and “early time points” method for mapping absolute CBF, using ultra-low contrast agent dose T1W-DCE-MRI. The new method was assessed using both computer simulation and in vivo data analysis in a patient with GBM, demonstrating that the new method performed better than previous approaches, e.g. MG-based methods, while using much lower dose than perfusion methods based on DSC-MRI.
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