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Abstract #5534

How people recover from extreme life stress: a longitudinal dynamic functional connectivity analysis

Jing Jiang1, Kaiming Li2, Xiaoqi Huang3, Su Lui3, Zhiyun Jia4, Qiang Yue3, Qiyong Gong3, and Qiyu Liu1

1Department of Radiology, Mianyang Central Hospital, Mianyang, China, 2Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, 3Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 4Huaxi MR Research Center (HMRRC), Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China

Dynamic functional connectivity (dFC) has provided more information than commonly-used static FC analysis. With dFC, we investigated the variation characteristics of three affected resting state networks, i.e., DMN, CEN and SN, in trauma-exposed non-PTSD group using resting state fMRI scans within 25 days and 2 years after Wenchuan earthquake. Results revealed increased connectivity was mainly involved in intra-network FC of DMN and inter-network FC between SN and DMN/CEN. Decreased connectivity was mostly found in intra-network FC of CEN and inter-network FC between CEN and SN. This study may provide insights of how people recover from extreme life stress from a FC variation perspective.

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