Abstract #5562

Impact of Carotid Endarterectomy on Functional Connectivity

Marc Lindley¹, Adam Bernstein^2,3, Chidi Ugonna², Denise Bruck⁴, Kevin Johnson⁵, Maria Altbach⁴, Lee Ryan⁶, Nan-kuei Chen², Ying-hui Chou⁶, Gloria Guzman⁴, Theodore Trouard², and Craig Weinkauf⁷

¹University of Arizona, Tucson, AZ, United States, ²Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ³NICHD, National Institutes of Health, Rockville, MD, United States, ⁴Medical Imaging, University of Arizona, Tucson, AZ, United States, ⁵Siemens Healthcare, Tucson, AZ, United States, ⁶Psychology, University of Arizona, Tucson, AZ, United States, ⁷Surgery, University of Arizona, Tucson, AZ, United States

Carotid endarterectomy (CEA) as a procedure has been shown effective in reducing the risk of stroke for patients with severe stenosis. The impact of CEA on the functional connectivity of the brain has not been assessed to this point. Nine patients underwent resting state fMRI pre-operatively and 1 month and 6 months post-operatively. Analysis was performed using seed based analysis and matrix based analysis to determine if there were functional connectivity changes as a result of CEA. Seed based and matrix based analysis showed that there were significant functional connectivity changes as result of CEA.

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