This study investigated the working memory-related brain activity to 3 different difficulty level n-back task before and after cessation treatment. Brain activation increased with increasing task difficulty in both control and smoker groups. The brain activation of smokers was higher than that of the control group, but the activation degree of smoking cessation treatment group was significantly lower than that before treatment, which was close to that of the control group. The result demonstrated varenicline’s cure effect on improving cognitive function, which was important to improve the withdrawal symptoms and increase smoking cessation rate.
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