The majority of previous studies concerning the brain network derived from resting state fMRI focused on a low frequency of signal oscillation from 0.01 to 0.1 Hz (Bullmore and Sporns 2009; Van Den Heuvel and Hulshoff Pol 2010). However, the frequency specificities with regard to the topological properties of the PD brain networks have not been fully revealed. To exam the frequency properties of Drug-naive and L-dopa-treated Parkinson's Disease Patients, we subdivided the low frequency range into five bands as previously defined (Biswal et al., 1995; Buzsáki and Draguhn, 2004; Penttonen, 2003). The results suggest that the subdivided frequency bands prominently dissociate topological organisation of brain networks between drug-naive PD patients and L-dopa- treated PD patients.
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