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Abstract #0013

Combined ventilation and perfusion imaging using dynamic susceptibility contrast 19F-MRI of inhaled perfluoropropane

Mary Neal1, Ben Pippard1, A John Simpson2, and Pete Thelwall1

1Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

19F-MRI of inhaled perfluoropropane (PFP) can be used to assess pulmonary ventilation. PFP has a short in vivo T2* (~2ms) arising from magnetic field inhomogeneity in the lung, reflecting the different magnetic susceptibilities of adjacent alveolar walls and gas components. Intravenous injection of a paramagnetic contrast agent to the pulmonary circulation can transiently reduce these magnetic susceptibility gradients, raising the T2* of inhaled PFP in regions directly adjacent to well-perfused lung. We present the first in man demonstration of combined pulmonary ventilation and perfusion assessment using 19F-MRI of inhaled PFP with concurrent administration of a gadolinium-based contrast agent.

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