Neurovascular coupling is the foundation of functional brain imaging. We developed a dual site, dual color simultaneous GCaMP6-based fiber photometry and fMRI recording system in rats, to simultaneously record calcium and BOLD signals. Our results revealed the strong couplings in the task condition, and much weaker but still significant coupling in the resting state. We also showed that in the resting state such coupling was susceptible to different preprocessing steps. Our results provided a novel perspective on neurovascular coupling in task and resting state conditions.
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