Jonas Lynge Olesen1,2, Noam Shemesh3, and Sune Nørhøj Jespersen1,2
1Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 2Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark, 3Champalimaud Neuroscience Programme, Lisbon, Portugal
A prevalent model for the diffusion signal from neural tissue is the so-called Standard model which represents axons as “sticks”, i.e., with zero radial diffusivity. Spinal cord tissue is characterized by larger axons than the brain which was recently shown to possibly invalidate the assumption up to large diffusion times. This calls for an appropriate extension of the Standard Model. Here, results from such an endeavour with an extensive dataset from a rat spinal cord are summarized. SM parameters were reliably estimated to be unphysical indicating that the model is insufficient in spinal cord white matter.
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