Meeting Banner
Abstract #0064

Temporal Diffusion Ratio (TDR): A Diffusion MRI technique to map the fraction and spatial distribution of large axons in the living human brain

Flavio Dell'Acqua1, Robert Dallyn1, Andrea Chiappiniello2, Ahmad Beyh1, Chantal Tax3, Derek K Jones3, and Marco Catani1

1NatBrainLab, King's College London, London, United Kingdom, 2Department of Physics and Geology, University of Perugia, Perugia, United Kingdom, 3CUBRIC, Cardiff University, Cardiff, United Kingdom

This work presents a new approach to mapping the fraction and spatial distribution of large axons (d>3μm) across white matter (WM) in the living human brain. By collecting high b-value (b=8000 s/mm2) diffusion MRI data at two diffusion times on a Connectome scanner, we were able to generate a new contrast specific to the characteristic signal decay of large axons at different diffusion times. Using this approach, we were able to identify and discriminate consistently some of the major WM pathways expected to carry the largest axons within the human brain. WM characterisation using TDR can offer important and practical clinical applications.

This abstract and the presentation materials are available to members only; a login is required.

Join Here