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Abstract #0079

White matter changes caused by mild traumatic brain injury in mice

Lisa M Gazdzinski1, Miranda Mellerup1,2, Tong Wang1,2, John G Sled3,4, Brian J Nieman3,4, and Anne L Wheeler1,2

1Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada, 2Physiology, University of Toronto, Toronto, ON, Canada, 3Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

White matter pathology following mild traumatic brain injury (mTBI) is complex and unlikely to be characterized by a single neuroimaging metric. DTI has been used to probe white matter microstructure, but is known to be non-specific. We show that the orientation dispersion index from the NODDI model may be more sensitive to white matter damage following mTBI in a mouse closed-skull impact model. Combined with quantitative susceptibility mapping, our data suggest minimal overt myelin loss, but progressive white matter injury, which may include myelin disruption, up to 6 weeks post-mTBI.

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